Ingenol mebutate in the treatment of actinic keratoses: clearance rate and adverse effects
نویسندگان
چکیده
منابع مشابه
Clinical Response to Ingenol Mebutate in Patients With Actinic Keratoses.
Cryotherapy is the most common treatment for actinic keratosis, but its effect is limited to individual lesions. Several topical drugs, however, are available that, in addition to treating individual actinic keratoses, target field cancerization and thereby act on subclinical lesions. Examples are 5-fluorouracil, imiquimod, diclofenac, and ingenol mebutate. We report on 17 patients with actinic...
متن کاملThe Role of Ingenol Mebutate in the Treatment of Actinic Keratoses
Actinic keratoses (AK) are the most common premalignant pathology seen in dermatological practice and represent a burgeoning burden upon health services. Increasingly recognized is the damage to surrounding, perilesional skin, forming the premise for field-directed therapy. Ingenol mebutate gel is a novel agent for field-directed treatment of AK, requiring only 2 or 3 days of application. Follo...
متن کاملIngenol mebutate gel (picato): a novel agent for the treatment of actinic keratoses.
Ingenol mebutate gel (Picato) for actinic keratoses.
متن کاملLong-term follow-up study of ingenol mebutate gel for the treatment of actinic keratoses.
IMPORTANCE Ingenol mebutate is the active agent (a macrocyclic diterpene ester) in the sap of the plant Euphorbia peplus. This herb has been used as a traditional remedy for several different skin lesions, including skin cancers. OBJECTIVE To assess 12-month recurrence rates and safety associated with ingenol mebutate gel treatment in patients who previously had achieved complete clearance of...
متن کاملTumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate
UNLABELLED The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted the first comprehensive analysis of the cellular and molecular mode of action of topical ingenol mebutate 0.05% gel in both AK and uninvolved skin of 26 patients in a phase I, single-center, open-label, within-patient compari...
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ژورنال
عنوان ژورنال: Anais Brasileiros de Dermatologia
سال: 2018
ISSN: 1806-4841,0365-0596
DOI: 10.1590/abd1806-4841.20186982